Abstract
The present work describes the diastereoselective Syntheses of α -epoxy- trans -disubstituted cyclopropane and α -hydroxy- trans -disubstitutedcyclopropane. The genesis of chirality in the targeted products is based on the exploitation of catalytic asymmetric transfer hydrogenation (CATHy) reaction. Asymmetric Cyclopropanation was carried out using Wadsworth–Emmons protocol. Among the surveyed conditions, employing TEPA, epoxide, NaH in toluene under reflux furnished the desired cyclopropane with 85% yield.
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