Abstract
A novel numerical method for solving fluid-structure interaction problems has been developed. A fixed-mesh approach is employed, and the basic equation set is solved in a finite-difference manner. The effectiveness of the simulation method is demonstrated. The methods has been extended to a multiscale simulator for the primary stage of thrombus formation as a result of a platelet adhesion to an injured vessel wall. The simulator treats continuum scale blood flows containing a large number of red blood cells (RBCs) and platelets, and also molecular scale ligand-receptor interactions by means of the stochastic Monte-Carlo method. The simulation results obtained using massively parallel computing on the K computer demonstrate the relevance of the RBC motion, which induces the fluctuating velocity of the surrounding liquid and causes the dispersed motion of the platelet, to the enhancement of the thrombus formation.
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