Abstract
3, 7 (9.2%): Ki67 negative, 33 (43.4%); positive, 43 (56.6%). The staining intensity of Skp2 and Cks1 showed significant linear correlation (Pearson's R 0.427, p < 0.01). Each staining intensity of Skp2 and Cks1 also showed significant linear correlations with the staining intensity of p27kip1, respectively (Pearson's R 0.314, p < 0.01 for Skp2 and p27kip1, Pearson's R 0.403, p < 0.01 for Cks1 and p27kip1). The positive immunostaining group for Ki67 showed significantly stronger immunostaining intensity for Skp2 (p < 0.01), Cks1 (p < 0.01) and cytoplasmic p27kip1 (p = 0.033). By Kaplan-Meier analyses, the higher IS (p = 0.018) and stronger immunostaining intensity (p < 0.01) of Skp2 and Cks1 were significantly associated with shorter survival for patients with extrahepatic cholangiocarcinoma. Conclusions: Overexpression of Skp2/Cks1 and aberrant localization of p27kip1 into cytoplasm might be useful predictors of prognosis in patients with extrahepatic bile duct cancer.
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