W1830 CD4+ T-Cell Depletion in Gut-Associated Lymphoid Tissue and CD8+ T-Cell Hyperactivation in Peripheral Blood are Linked to Greater Gut-Proportion of Enterobacteriales and Bacteroidales in HIV Therapy Pre-Clinical Trial Analysis

Abstract

thy) and histologic (epithelial erosions, crypt hyperplasia, mononuclear cellular infiltrate) lesions were inversely associated with changes in composition of the intestinal microbiota of IL-10-/mice at all time points. Conclusions: Changes in the relative densities and spatial distribution of dominant bacterial groups occur and precede the development of colitis in IL-10-/mice. Archaea decreased in colitic IL-10-/mice and appear to associate with different bacterial species during active inflammation. These results indicate that the Archaea (methanogens) may serve as a biomarker for onset and progression of IBD. Further work on the diversity of methanogens as well as alterations in the concentration of methanogenic species is required to fully assess their biomarker potential.