Abstract
G A A b st ra ct s Our study suggest that impaired butyrate oxidation is closely linked to the sulphide detoxification capacity of the mucosa in ulcerative colitis. The sulphide detoxification mechanism could explain the well-documented observation that cigarette smoking is beneficial in UC. Smoking increases blood cyanide levels and the colon has been shown to extract cyanide from blood. Hence, this cyanide could enhance the removal of thiosulphate from the colonic mucosa and thus facilitate the metabolism of sulphide to thiosulphate.
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