Abstract
10). CCK sensitive currents are also abolished by 2-APB, ruthenium red and SKF96365. Widespread immunoreactivity was seen for all TRPC subunits. Conclusions: NGNs exhibit currents activated by known agonists of TRPC channels. The OAG activated current most closely resembles TRPC1 with near linear I/V relationship. However the current sensitive to the nonselective TRPC blockers 2-APB and SKF96365 is more complex, likely reflecting a composite of TRPC1 and possibly TRPC4 and / or 5, as these subunits can heterodimerize. The presence of currents similar to TRPC1 is relevant for gastrointestinal vagal afferents, as this channel is known to also be mechanosensitive. TRPC channels may integrate the complex chemical and possibly mechanical stimuli which activate vagal afferents.
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