W1327 Exaggerated Rectal Tone Response After Meal Intake in Patients with Irritable Bowel Syndrome with Fecal Incontinence

Abstract

the methane excretors into 4 different patterns: type 1= constant excretion throughout the breath test; type 2= parallel increase of both gases; type 3= reduction of methane excretion when hydrogen increases; type 4= increase in methane excretion, no hydrogen modification. Presence and severity of bloating, flatulence, abdominal pain and borborygmi were evaluated by a scale where 0=no symptom, 3= severe symptom. We also estimated mouth-to-cecum transit time by the lactulose breath test. Results: The prevalence of methane excretors was similar between IBS-C and IBS-D patients (44% vs 42%, respectively, chi-square=NS). methane excretors in comparison with non-excretors showed no difference in the prevalence of bloating (94% vs 91%), flatulence, (87% vs 83%), abdominal pain (85% vs 89%), borborygmi (85% vs 80%); in the severity of bloating (2±1 vs 2±1), flatulence, (1.5±1 vs 1.4±1), abdominal pain (1.6±1 vs 1.7±1), borborygmi (1.4±0.9 vs 1.5±1); in mouth-tocecum tansit time (115±47 min vs 109±38 min). There was no correlation between severity of each symptom and cumulative methane excretion. However, type 2 methane excretors showed a significantly higher prevalence of bloating. Conclusion: In a large sample of IBS patients there is no association between cumulative methane excretion and prevalence of symptoms, but in the subgroup of patients showing both methane and hydrogen excretion increase after lactulose, bloating is more prevalent.