W1322 The Practice of North-American Gastroenterologists in Treating IBD Patients With C.Difficile: Antibiotics Alone or Combined Antibiotics-Immunomodulators?

Abstract

and suspect types were 4(7.4%), 23(42.6%), 27(50.0%) patients, respectively. The median dosage of corticosteroid was 0.58mg/kg (0.39-1.20). There were 25(46.3%) cases with complete remission, 23(42.6%) with partial remission, and 6(11.1%) patients showed no response to corticosteroid therapy after 1 month post-treatment. Three months after the treatment, 22(40.7%) showed prolonged response, 25(46.3%) showed steroid dependency, 3(5.6%) showed refractoriness and 4 (7.4%) received operation respectively. At 1 year, there were 26(48.1%) patients in prolonged response, 19(35.2%) in corticosteroids dependency, and 4(7.4%) that received operation. The cumulative probability of surgery was 17.5% and 49.1% at 1 and 3 years, respectively. Prolonged response at three months was independently associated with decreased risk of surgery in the long-term (P=0.009, HR 0.176, CI 0.0480.649). Conclusions: Short-term response rate to initial corticosteroid therapy in IBD was high, however the responses showed a decreasing tendency along with time. Prolonged response at three month was associated with decreased risk of surgery in the long-term.