W1100 Intragastric pH Holding Time of pH

Abstract

Introduction We have previously proposed a linear relationship between the degree and duration of suppression of 24-h intragastric acidity and the healing rate of erosive esophagitis (EE) with the best predictor as per cent time pH ≥4. Poor response to PPI is an increasingly important concern. Simply reporting time pH Methods A meta-analysis was performed to provide 24-h intragastric pH values at steady state (day 5–8) in healthy volunteers and the EE healing rate at 4 or 8 weeks, by searching the English-language literature up to June 2009 in MEDLINE and EMBASE. For pH data, a weighted mean is only possible by using the sample size of each arm ((mean×n from each study)/Σ treated N). A regimen was excluded if Result 95 studies (411 arms) provided intragastric pH data and 109 studies (243 arms) provided EE healing data for 3 H2-RAs, 5 PPIs and placebo. The commonly reported pH parameter in the pH-EE model was mean per cent time pH Conclusion Any increase in the time intragastric pH is pH