Abstract
Introduction. – There is little information available on the events that mediate short term remodeling. In a bigeminy atrial-pacing protocol, we sought to evaluate the electrophysiological consequences of an irregular short-long cycle length atrial pacing. Methods and results. – This study included 22 consecutive patients with documented arrhythmias and 10 control subjects. After evaluating the effective and functional refractory periods, bigeminy atrial pacing was performed for 5 min. During bigeminy pacing, in 12 AF patients and in none of the control subjects, AF was started lasting longer than 1 minute (Group I). Short salvos of AF occurred in five patients and three controls (Group II) and no arrhythmia occurred in five patients and seven controls (Group III). Sensitivity, specificity, negative and positive predictive values of sustained AF induced by bigeminy pacing were 54%, 100%, 50% and 100%, respectively. Atrial refractory periods measured immediately after termination of 5 minutes of bigeminy pacing were shorter than during baseline. The degree of shortening was similar in AF patients and in controls. The loco-regional conduction did not change after the bigeminy protocol. Conclusion. – This study demonstrates that atrial bigeminy pacing unmasks latent atrial vulnerability.
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