Abstract
Single fibre EMG was used to study the motor unit fibre density in the right biceps brachii, extensor digitorum communis and first dorsal interosseous muscles of 15 patients with motor neurone disease, with different patterns of initial weakness. There was an inverse relationship between strength and fibre density in these muscles. Abnormalities were more marked in patients whose initial symptom was arm weakness, but collateral reinnervation was not as effective as in other neurogenic disorders. These findings are consistent with a hypothesis that motor neurone disease begins segmentally, or at a discrete level within the motor system, before becoming generalised. The single fibre EMG fibre density is a useful quantitative technique for sequential assessment of patients with neurogenic disorders.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
