Abstract
The heads of 7-day-old rats were exposed to X-irradiation (600 r) and the animals allowed to survive to 7.5 months of age when their brains were examined. There was a large, selective, residual deficit of cerebellar weight amounting to 61% of controls. The deficit in number of cells was somewhat less than the deficit in weight, leading to a substantial increase in its cellularity. These changes were accompanied by residual deficits in cholesterol concentration, especially in the brain stem. The results provide yet another example of the differential susceptibility of the cerebellum when its growth is interfered with at a time when it is normally growing rapidly. Permanent deficits have been induced at a late stage of development corresponding approximately to the perinatal period of human brain growth.
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