VP44.24: The association between cervical elastography and adverse pregnancy outcome in pregnancy with placenta previa

Abstract

To investigate the association between cervical elastographic parameters and adverse pregnancy outcome in pregnancy with placenta previa. This retrospective cohort study included 64 pregnant women with placenta previa who had examined cervical elastography using E-cervixTM (WS80A, Samsung Medison, Seoul, Republic of Korea) at 20–34 weeks of gestation from 2019 to 2020 at Severance Hospital. Clinical characteristics and commercially available elastography parameters (IOS, EOS, ECI and HR) were compared with or without adverse outcome. Adverse pregnancy outcome included spontaneous preterm delivery (sPTD) < 37 weeks or admission due to excessive vaginal bleeding. Cervical elastographic and pregnancy outcomes were analysed using the Chi-square test, Mann-Whitney U test, and logistic regression analysis adjusted by cervical length and gestational age at examination. 64 pregnant women enrolled in this study and 124 cases of cervical elastography were acquired. Of them, 19 (29.6%) had sPTD < 37 weeks and 23 (35.9%) had admitted to hospital with excessive vaginal bleeding. Adverse pregnancy outcome group had higher IOS and ECI than those of the control group (p = 0.006 and 0.047, respectively). The odds of adverse pregnancy outcome increased by 1.11-fold for each 0.1 increase in IOS (adjusted for cervical length and gestational age at examination; p = 0.003). In combination with elastographic parameters, IOS*ECI and IOS*HR were associated with adverse pregnancy outcome. On logistic regression analysis, IOS*ECI (odds ratio [OR], 5.32; p = 0.009) and IOS*HR (OR, 1.23; p = 0.003) were independent predictors of adverse pregnancy outcomes. Cervical elastography may be useful for the prediction of women with placenta previa for adverse pregnancy outcomes.