Abstract
The management of gMG is changing with the advent of targeted therapeutics and an expanding pipeline. HCPs need to know how to use biomarkers and antibody testing to better individualize therapeutic decisions. We assessed the impact of online continuing medical education (CME) for clinicians (HCPs) on competence related to generalized myasthenia gravis (gMG) diagnosis and knowledge of current and new and emerging treatment options. One 60-min CME activity was launched live-online on 3/9/21 and remained on-demand for 1 year. Test questions were administered pre-, immediately post-, and 2 months post-activity. Responses from learner polling and follow-up surveys were analyzed for engagement, lessons learned, and continuing gaps. Chi-square compared paired responses (pre/post & pre/2 mos, p<.05). When the activity expired, 906 HCPs engaged with the activity, 223 of them reporting 9.4 patient visits for MG every month. Results showed statistically significant immediate increases in knowledge related to treatment-resistant gMG disease burden (76% post vs 30% pre), therapeutic predictive value of gMG associated antibodies (84% post vs 39% pre), and mechanisms of action of new immunoglobulin G (IgG) and emerging neonatal Fc receptor (FcRn) targeted agents (87% post vs 39% pre). During the follow-up survey, 88% of HCPs reported the education to benefit their clinical practice, with write-in examples of changes related to implementation of EMG and antibody testing for diagnosis, increased awareness of new treatments options, and enhanced ability to provide patient counseling regarding management options. These data support the positive impact of live and on-demand online CME education on awareness of gMG burden, diagnosis, prognosis based on biomarkers, and its evolving management. The education also revealed areas in need for continuous education regarding the impact on gMG burden on treament selection, and strategies to individualize therapy.
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