VP31.08: Placental profiling in women with confirmed COVID‐19 infection

Abstract

to profile the typical lesion characteristics found in placentas of women with COVID-19. Consecutive placental specimens were acquired from pregnant women with confirmed COVID-19 infection by RT-PCR delivering between May 2019 – June 2021 in a tertiary reference hospital. Histological analysis of the placenta was carried out by the same pathologist in all cases and categorised according to the Amsterdam classification for histopathology analysis of the placenta. A principal component analysis was performed to assess the typical placental profile in women with COVID-19 infection. A total of 351 positive-COVID-19 consecutive placentas were analysed. Three main COVID-19 placental profiles were found after principal component analysis. The first profile comprised maternal venous malperfusion, deciduitis, thrombosis, and atherosis with absence of chorioamnionitis, explaining 16% of all placentas. The second placental profile was made of fetal venous malperfusion, placental chorangiosis, thrombosis with absence of atherosis and fibrinoid necrosis explaining 13% of all observations. The third profile comprised placental villitis, thrombosis, and fibrinoid necrosis with absence of fetal venous malperfusion, and deciduitis, explaining 12% of all observations. The most common COVID-19 placental lesion profile comprises maternal venous malperfusion, deciduitis, thrombosis, and atherosis followed by fetal venous malperfusion, placental chorangiosis, and thrombosis. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.