Abstract
VP16-213 is a new semisynthetic podophyllotoxin derivative, which appears to have a unique mode of action. Early suggestive data of activity in small cell lung cancer [21, 25] have ben confirmed and the single-agent response rate remains at over 40% with well more than 200 patients studied. It also shows a pronounced antitumor activity in the treatment of testicular cancer, monocytic or myelomonocytic leukemia, non-Hodgkin's lymphomas and hepatocellular carcinoma. Its role in some other neoplasms, like non-small cell lung cancer and breast cancer, has still to be ascertained.
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