Abstract

Voxel-wise absorbed dose distributions, γ-index agreement test and dose-volume histograms (DVH) for the evaluation of dose distributions have been used in stereotactic body radiotherapy (SBRT) for several years. Our research group recently adapted these concepts to liver radioembolization (RE) using Yttrium-90 (90Y) glass microspheres (MS). In this work we demonstrate the application of our dosimetry tools to study the dose distributions within the tumor (PTV) and normal liver (NLV) tissues of a patient treated with multiple radiation therapies (RE after SBRT). Voxel-wise biological effective dose (BED) distributions from SBRT and RE were computed and added up. Moreover, we investigated the role of pre-treatment single-photon emission computed tomography (SPECT) in the planning dosimetry of RE.

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