Abstract
Voxel-based morphometry (VBM) is widely used to help diagnosing Alzheimer's disease. It is certainly a convenient tool and the prevalence of Magnetic resonance imaging (MRI) enhance its usefulness. To clarify the actual power of VBM targeting atrophy in the medial temporal lobes, we retrospectively compared amyloid positron emission tomography (PET) and VBM. Two hundred and seventeen patients who underwent both Pittsburgh Compound B (PiB) PET and nuclear magnetic resonance imaging (MRI) were retrospectively recruited. 97 patients were amyloid negative and 120 were amyloid positive. Voxel-Based Specific Regional Analysis System for Alzheimer's Disease (VSRAD®) Z scores of patients between PiB negative and positive were significantly different (p=0.0055). However, histogram showed vast overlap between PiB positive and negative. Area Under the Curve (AUC) of Receiver Operating Characteristic (ROC) curve was only 0.64. Sensitivity was 0.75, specificity was 0.67 at the cutoff level of 1.23. Hippocampal atrophy could not differentiate amyloid positivity reliably.
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