Abstract
We report a 52-year-old woman with vortex keratopathy (cornea verticillata) of unknown cause in whom multiple myeloma was found 18 months later. Surgical biopsy of conjunctival crystalline deposits, which were stained immunohistologically and analyzed ultrastructurally, as well as hematologic workup for multiple myeloma, were performed. Light microscopy of conjunctival deposits revealed plasmacytoid infiltrates in the conjunctiva, which stained monoclonally for immunoglobulin G (IgG)-kappa light chains. Transmission electron microscopy showed intracellular hexagonal crystalline structures and extracellular microfibrils. Hematologic tests confirmed the diagnosis of multiple myeloma. Multiple myeloma is one of the many causes of vortex keratopathy.
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