Abstract

Light and electron microscopic studies of lymphadenitis in human typhoid fever are presented. Gram-negative bacteria could be observed in phagosomes within typhus cells as well as in extracellular spaces. Intracellular bacteria were small and coccoid in shape. The extracellular bacteria were larger and strongly stained. Ingested bacteria had formed small groups, suggesting intracellular multiplication similar to intracellular parasitism in cases of animal salmonelloses.

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