Abstract
Cachexia develops in the course of many chronic diseases such as malign tumours, chronic heart failure, chronic kidney failure, rheumatoid arthritis, or AIDS. In most cases, the development of cachexia worsens morbidity and mortality of the underlying disease. Unfortunately, the term „cachexia” is still not routinely used by clinicians, although the clinical impact of cachexia is difficult to overestimate. The reasons include the difficult question of a uniform definition of cachexia, but also the absence of specific therapies. The aim of this article is to provide an overview of the pathophysiology and potential therapeutic approaches to cachexia in chronic heart failure. We particularly discuss the role of inflammation and the regulation of appetite.
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