Abstract
The structure determination of membrane proteins by X-ray crystallography is plagued by two major bottlenecks: the use of compromising detergents for protein extraction and purification as well as the necessity to harvest small crystals. With the aid of polymer-bounded lipid nanodiscs, membrane proteins can be crystallized without ever removing the protein from a lipid bilayer. New in situ strategies, where data are collected from unperturbed crystals, avoid crystal harvesting.
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