Abstract
Oxidative stress plays a key role in the onset and development of diabetes complications. In this study, we evaluated whether voluntary exercise could alleviate oxidative stress in the heart and blood of streptozotocin - induced diabetic rats. 28 male Wistar rats were randomly divided into four groups (n=7): control, exercise, diabetes and exercise + diabetes. Diabetes was induced by injection of streptozotocin in male rats. Rats in the trained groups were subjected to voluntary running wheel exercise for 6 weeks. At the end of six weeks blood and heart tissue samples were collected and used for determination of antioxidant enzymes (including SOD, GPX and CAT activities) and MDA level. Exercise significantly reduced MDA levels both in the heart tissue (p<0.01) and blood samples (p<0.05). In addition, exercise significantly increased SOD (p<0.05), GPX (p<0.001) and CAT (p<0.05) in the heart tissue. Voluntary exercise also significantly increased SOD (p<0.01), GPX (p<0.05) and CAT (p<0.001) in the blood. Voluntary exercise diminishes the MDA level in blood and heart tissue of diabetic rats. It also accentuates activities of SOD, GPX and CAT. Therefore, it may be considered a useful tool for the reduction of oxidative stress in diabetes.
Highlights
Diabetes mellitus, a chronic and progressive metabolic disorder, is a challenging public health problem and nowadays, diabetes-related complications are one of the most important contributing mortality factors in the world.[1]
Lipid peroxidation In the heart tissue, the level of MDA increased in diabetes group (p < 0.05), and decreased in diabetes + exercise group (p < 0.01), but the levels of MDA showed no change in exercise group compared to control group
Diabetes induced oxidative stress demonstrated by high level of MDA and diminished antioxidant enzymes activities which is reversed by voluntary exercise
Summary
A chronic and progressive metabolic disorder, is a challenging public health problem and nowadays, diabetes-related complications are one of the most important contributing mortality factors in the world.[1]. Many beneficial effects of exercise such as increasing insulin sensitivity, improved glucose uptake and alleviating diabet complications in diabetic animals and patients are reported.[4,5,6,7,8] Exercise is a modifiable behavioral factor which can produce several beneficial effects, including improved cardiac functions and diabetes complications.[9] Exercise training has been reported to increase SOD10,11 and partially reverses oxidative stress in the brains of ethanol-exposed rats.[12] Malondialdehyde plasma levels were significantly reduced in streptozotocin-induced diabetic rats submitted to forced swimming test and that the associated treatment of insulin and clonazepam.[13] In the animal model of voluntary exercise the animal has free access to a running wheel and uses the wheel according his physiological threshold for physical activity. The aim of this study is to investigate the effect of voluntary exercise on oxidative stress in the heart and blood of diabetic male rats
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