Volumetric studies of antibiotics in aqueous media

Abstract

Acoustical and volumetric studies of antibiotics; dimetridazole (DMZ) and metronidazole (MNZ) were carried out to understand the various interactions present in antibiotic's aqueous solutions. Density and speed of sound of antibiotic solutions in water with the molality ranging (0.01–0.05molkg−1) were measured over the temperature range from 293.15K to 313.15K. Volumetric and acoustical properties like apparent molar volume (Vϕ), adiabatic compressibility factor (Ks), isentropic compressibility (Kϕ), partial molar volume (V°ϕ) and partial molar compressibility (K°ϕ) of antibiotics were calculated from the experimental data of density and sound velocity. The derived data has been discussed in terms of solute-solute and solute-solvent interactions. The Vϕ values are positive and Kϕ values are negative for both antibiotics, indicative of strong solute-solvent interactions and closely packed structure of antibiotics in water.