Abstract
In this work, we examine the volumetric flow rate of microfluidic devices. The volumetric flow rate is a parameter which is necessary to correctly set up a simulation of a real device and to check the conformity of a simulation and a laboratory experiments [1]. Instead of defining the volumetric rate at the beginning as a simulation parameter, a parameter of external force is set. The proposed hypothesis is that for a fixed set of other parameters (topology, viscosity of the liquid, …) the volumetric flow rate is linearly dependent on external force in typical ranges of fluid velocity used in our simulations. To confirm this linearity hypothesis and to find numerical limits of this approach, we test several values of the external force parameter. The tests are designed for three different topologies of simulation box and for various haematocrits. The topologies of the microfluidic devices are inspired by existing laboratory experiments [3 - 6]. The linear relationship between the external force and the volumetric flow rate is verified in orders of magnitudes similar to the values obtained from laboratory experiments.
Highlights
The research group Cell in fluid is interested in modelling of elastic objects in fluid flow in solid channels, in order to simulate the flow of the plasma and blood cells in microfluidic devices
Afterwards, we ran the simulations without Red Blood Cells (RBC), in order to include more realistic haematocrit in the laboratory experiments. 2.1 Cylindrical adhesive topology – capturing of Circulating Tumour Cells (CTC) by antibodies-coated obstacles in micro channel First tested topology is inspired by works [3] and [4]
Cylindrical adhesive topology The initial value of the external force parameter for the simulation without RBCs was set to 0.000007, which results in volumetric flow rate of 4,48 4 μm3/μs
Summary
The research group Cell in fluid is interested in modelling of elastic objects in fluid flow in solid channels, in order to simulate the flow of the plasma and blood cells in microfluidic devices. The numerical simulation of such a device is faster and cheaper to establish, compare with the fabrication of the real microchip. The long-time goal of the group is to make models of the microfluid devices capturing Circulating Tumour Cells (CTC). At today’s stage of the software’s development, some calibration calculations are needed, to compare the results of the numeric simulations with results of laboratory experiments. In order to do so, the input parameters influencing the movement of the cells in the blood plasma have to be the same, such as the viscosity of the liquid, the hematocrit, or the volumetric flow rate
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