Volumetric approach to the interaction of L-Proline in aqueous Metformin Hydrochloride solutions for temperature range 298.15–318.15 K

Abstract

Densities ρ, have been measured for l-Proline in aqueous Metformin Hydrochloride solutions of (0.05, 0.10, 0.15 and 0.20 M) mol kg−1 at T = 298.15–318.15 K. Apparent molal volumes Vφ have been determined from the experimental densities. These data have been used to calculate several thermodynamical parameters such as standard partial molal volume Vφ0, transfer volume ΔtrVφ0, hydration number nH, the second derivative of infinite dilution of partial molal volume with respect to temperature, viz., ∂2Vφ0/∂T2. Furthermore apparent molar expansibility E0, thermal expansion coefficient, α2 and the pair and triplet interaction coefficient have been calculated and reported. These results interpreted through a co-sphere overlap model indicate the presence of strong solute-co-solute interactions in the reported systems.