Volumetric, Acoustic and Transport Properties of Metformin Hydrochloride Drug in Aqueous d-Glucose Solutions at T = (298.15–318.15) K

Abstract

Apparent molar volumes, apparent molar adiabatic compressibilities and viscosity B-coefficients for metformin hydrochloride in aqueous d-glucose solutions were determined from solution densities, sound velocities and viscosities measured at T = (298.15–318.15) K and at pressure p = 101 kPa as a function of the metformin hydrochloride concentrations. The standard partial molar volumes ( $$ \phi_{V}^{0} $$ ) and slopes ( $$ S_{V}^{*} $$ ) obtained from the Masson equation were interpreted in terms of solute–solvent and solute–solute interactions, respectively. Solution viscosities were analyzed using the Jones–Dole equation and the viscosity A and B coefficients discussed in terms of solute–solute and solute–solvent interactions, respectively. Adiabatic compressibility ( $$ \beta_{s} $$ ) and apparent molar adiabatic compressibility ( $$ \phi_{\kappa }^{{}} $$ ), limiting apparent molar adiabatic compressibility ( $$ \phi_{\kappa }^{0} $$ ) and experimental slopes ( $$ S_{\kappa }^{*} $$ ) were determined from sound velocity data. The standard volume of transfer ( $$ \Delta_{t} \phi_{V}^{0} $$ ), viscosity B-coefficients of transfer ( $$ \Delta_{t} B $$ ) and limiting apparent molar adiabatic compressibility of transfer ( $$ \Delta_{t} \phi_{\kappa }^{0} $$ ) of metformin hydrochloride from water to aqueous glucose solutions were derived to understand various interactions in the ternary solutions. The activation parameters of viscous flow for the studied solutions were calculated using transition state theory. Hepler’s coefficient $$ (d\phi /dT)_{p} $$ indicated the structure making ability of metformin hydrochloride in the ternary solutions.