Abstract
In the sensory ganglion, just as in the CNS, neurotransmitter and gliotransmitters have profound effects on pain behavior. Current evidence indicates that ATP, CGRP and TNF-alpha are serving as neuro/glio neurotransmitters within the sensory ganglion. In this enclosed area where there are no synapses, transmitters are released in a narrow gap, the size of a synaptic cleft, separating sensory neurons from satellite cells. We have now evidence that glutamate is released within the ganglion. Initially, we found that silencing the glutamate transporter GLAST in the ganglion leads to an increase in pain behavior in a reversible manner.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.