Abstract
The interaction of pentoxifylline (PTX) with Zn(II) in the presence and absence of cysteine at physiological pH (7.40) was investigated for the first time by square-wave and cyclic voltammetry techniques. The Zn(II)–PTX complex was found to be an electroinactive inert complex, the composition of the formed complex is 1 : 1 (metal : ligand), and the logarithm of its stability constant (log β1 : 1) was determined as 3.46 by direct monitoring of the current of free zinc(II). The logarithm of the stability constant (log β1 : 2) and stoichiometry of the complexation of Zn(II) with cysteine were determined to be 9.94 and 1 : 2, respectively. The stability constants were in agreement with those calculated from electronic spectral data. In the presence of cysteine, Zn(II)–PTX dissociated and an irreversible peak for Zn(II)–cysteine appeared at −1.342 V. Cysteine prevents complex formation of Zn(II) with PTX.
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