Abstract
Sodium dodecyl sulphate (SDS) surfactant immobilized carbon paste electrode has been proposed for investigation and determination of trimethoprim by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The electro analytical determination of trimethoprim was carried out in phosphate buffer solution at pH 3.0. The analyte showed one well-resolved irreversible oxidation peak at around 1141 mV, which served as the analytical response. The variation of pH, scan rate, concentration of trimethoprim has been studied. The limit of detection (LOD) and limit of quantification (LOQ) of trimethoprim were found to be 0.14µM and 0.48µM, respectively. From the studies of scan rate effect the overall electrode process was found to be diffusion controlled. SDS modified carbon paste electrode showed good electro catalytic effect towards the detection of trimethoprim.
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