Voltammetric studies of the interaction of metal chelates with DNA. 2. Tris-chelated complexes of cobalt(III) and iron(II) with 1,10-phenanthroline and 2,2'-bipyridine

Abstract

Voltammetric methods were used to probe the interaction (electrostatic or intercalative) of metal complexes, ML 3 3+/2+ , with calf thymus DNA. Binding constants (K n+ ) and binding site sizes (s) were determined from voltammetric data. The exact magnitude for the parameters depends on whether the ML 3 3+/2+ /DNA reaction is assumed to be static (S) or mobile (M) within the characteristic time of a voltammetric experiment