Abstract
Electrochemical oxidation of loop diuretic furosemide (4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid) was studied in 5.0 pH with 0.04 M Britton–Robinson buffer as supporting electrolyte at 25 ± 0.1 °C at a multi-walled carbon nanotubes-paraffin oil paste electrode (CNTPE) using cyclic and differential-pulse voltammetric (DPV) techniques. The electrochemical process was observed to be adsorption controlled, irreversible and involving two-electron oxidation. Effects of anodic peak potential ( E pa), anodic peak current ( I pa) and heterogeneous rate constant ( k 0) have been discussed. Under optimal conditions, the peak current was proportional to furosemide concentration in the range of 8.0 × 10 −6 to 2.0 × 10 −4 M with a detection limit of 2.9 × 10 −7 M by differential pulse voltammetry. A differential pulse voltammetric method with good precision and accuracy was developed for the determination of furosemide in pharmaceutical formulations and urine as a real sample.
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