Abstract
In this work, the gold nanoparticles (Au NPs)/multi-walled carbon nanotubes (MWCNTs) composite film modified glassy carbon electrode (GCE) was fabricated, and scanning electron microscopy (SEM) was used to investigate the assemble process of the composite film. In pH 7.0 PBS, a oxidation peak of the vitamin B6 (VB6) was only observed at composite film modified electrode. Under the optimized conditions, the current intensity was linear with the concentrations of VB6 in the range of 1.59 to 102.74 μg●mL–1 with a detection limit of 0.53 μg●mL–1 (S/N = 3). The modified electrode had been applied in medication analysis, and obtained good results.
Highlights
Vitamin B6 (VB6), known as pyridoxine, is part of the B group vitamins and plays an important role in the synthesis and metabolism of amino acid
Vitamin B6, Vitamin B1 (VB1), Vitamin B2 (VB2), Ascorbic acid (AA), and HAuCl4·4H2O were obtained from Shanghai Chemical Reagent Co., Ltd (China)
It was observed that the MWCNTs distributed uniformly on the surface of glassy carbon electrode (GCE) and Au NPs had been uniformly decorated onto the surface of MWCNTs (Figure 1(b))
Summary
Vitamin B6 (VB6), known as pyridoxine, is part of the B group vitamins and plays an important role in the synthesis and metabolism of amino acid. Several analytical methods have been described in literature for determination of VB6, including spectrophotometry [2,3], liquid chromatogramphy [4,5] and electrochemistry method [6,7]. Fang et al [9] detected VB6 in pharmaceutical preparations by micellar electrokinetic chromatography with amperometric electrochemical method. Söderhjelm and Lindquist [10] firstly detected VB6 in pharmaceutical preparations with electrochemical method; the interferences from ascorbic acid were existed and had not been repelled. Few papers had been described on the determination of VB6 using electrochemical method
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