Abstract
The electrochemical behavior of Sulfaclozine Sodium (SLC) was studied at a bare and sephadex-modified carbon paste electrodes by cyclic voltammetry and square wave voltammetry. The cyclic voltammetry (CV) showed a well-defined irreversible oxidation peak at 0.94 V in Britton- Robinson buffer pH 7.0. The strong affinity of SLC to sephadex allowed accumulation of SLC at the surface of electrode and thus higher electrochemical sensitivity to SLC. The influence of sephadex loading, the pH of the solution and the scan rate on the peak current was studied. A linear calibration curve covering the concentration range from 0.005 to 1 mM was obtained using SWV. The method was successfully applied for the determination of SLC in the veterinary pharmaceutical formulations with satisfactory accuracy and precision.
Highlights
Coccidiosis is a parasitic disease that attacks the intestinal tract of poultry caused by protozoan parasites of the genus Eimeria
The electrochemical behavior of SLC was studied at the carbon paste by recording the cyclic voltammetry (CV) from 0 to 1.4 V in BR pH 7
We report for the first time a novel simple and rapid Square Wave Voltammetry (SWV) method for SLC determination in veterinary formulations
Summary
Coccidiosis is a parasitic disease that attacks the intestinal tract of poultry caused by protozoan parasites of the genus Eimeria. This disease is of worldwide occurrence and costs the poultry industry many millions of dollars every year to control.[1] live vaccines were introduced, prophylactic chemotherapy is still preferred for coccidiosis control in most countries. The last half of the twentieth century marked improvements in the performance of commercially reared poultry. These improvements would not be possible without the introduction of a succession of ever more effective anticoccidial agents to control coccidiosis.[2].
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