Abstract
We used MoS2 nanosheets (MoS2 NSs) for surface modification of screen-printed electrode (MoS2NSs-SPE) aimed at detecting isoniazid (INZ) in the presence of acetaminophen (AC). According to analysis, an impressive catalytic performance was found for INZ and AC electro-oxidation, resulting in an appreciable peak resolution (~320 mV) for both analytes. Chronoamperometry, differential pulse voltammetry (DPV), linear sweep voltammogram (LSV), and cyclic voltammetry (CV) were employed to characterize the electrochemical behaviors of the modified electrode for the INZ detection. Under the optimal circumstances, there was a linear relationship between the peak current of oxidation and the various levels of INZ (0.035–390.0 µM), with a narrow limit of detection (10.0 nM). The applicability of the as-developed sensor was confirmed by determining the INZ and AC in tablets and urine specimens, with acceptable recoveries.
Highlights
Graduate University of Advanced Technology, Kerman 7631885356, Iran; Abstract: We used MoS2 nanosheets (MoS2 NSs) for surface modification of screen-printed electrode (MoS2 NSs-SPE) aimed at detecting isoniazid (INZ) in the presence of acetaminophen (AC)
Drug analysis has used a variety of analytical techniques such as high-performance liquid chromatography (HPLC) [1,2], mass spectrometry [3], liquid chromatography–mass spectrometry/mass-spectrometry (LC–MS/MS) [4], and chemiluminescence [5–7]
Analytical approaches based on electrochemical sensing systems possess multiple merits such as cost-effectiveness, portability, simple devices, narrow limit of detection (LOD), high-speed analysis, extended linear dynamic range, and selectivity in exposure to interferants [8–12]
Summary
A potentiostat/galvanostat AUTOLAB PGSTAT 302N (Metrohm, Herisau, Switzerland) was utilized to carry out all experiments during the electrochemical processes, under monitoring of the General Purpose Electrochemical System (GPES) software Version 4.9. A Metrohm 713 pH meter (Metrohm, Herisau, Switzerland) equipped with a glass electrode was utilized to measure the pH values of all solutions. Deionized water from Direct-Q®® 8 UV water purification system (Millipore, Darmstadt, Germany) was applied to freshly prepare all solutions. Fourier-transform infrared (FTIR) patterns were obtained from a Tensor II spectrometer (Bruker, Mannheim, Germany). Energy dispersive X-ray (EDX) patterns and scanning electron microscopy (SEM) images were obtained by the MIRA3 scanning electron microscope (Tescan, Brno, Czech Republic). Phosphoric acid was utilized to prepare phosphate buffer solutions (PBSs) with various pH values adjusted by NaOH
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