Abstract
The preparation and electrochemical characterization of a carbon paste electrode modified with N,N'-ethylenebis(salicylideneiminato)oxovanadium(IV) complex ([VO(Salen)]) as well as its behavior as electrocatalyst toward the oxidation of dipyrone were investigated. The electrochemical behavior of the modified electrode and the electrooxidation of dipyrone were explored using cyclic voltammetry. The voltammetric response of the modified electrode is based on two reactions. One electrochemical related to the oxidation of the metallic center of the [VO(Salen)] and the other involving the chemical redox process involving the oxidized form of the complex and the reduced form of dipyrone. The best voltammetric response was observed for a paste composition of 25% (m/m) [VO(Salen)], KCl solution pH from 5.5 to 8.0 as the electrolyte and potential scan rate of 10 mV s-1 in the presence of dipyrone. A linear voltammetric response for dipyrone was obtained in the concentration range from 9.9 x 10-6 to 2.8 x 10-3 mol L-1, with a detection limit of 7.2 x 10-6 mol L-1. Among of several compounds tested as potential interference, only ascorbic acid presented some interference. The proposed electrode is useful for the quality control and routine analysis of dipyrone in pharmaceutical formulations.
Highlights
IntroductionThe dipyrone (sodium salt of the 1-phenyl-2,3-dimethyl4-methyl aminomethane sulfonate-5-pyrazolone), is a water
The preparation, properties and application of a carbon paste electrode modified with the N,N-ethylenebis(salicylideneiminato) oxovanadium(IV) complex ([VO(Salen)]) for voltammetric determination of dipyrone in pharmaceutical formulations is reported
The voltammetric behavior of the modified electrode was investigated in 0.1 mol L-1 KCl solution
Summary
The dipyrone (sodium salt of the 1-phenyl-2,3-dimethyl4-methyl aminomethane sulfonate-5-pyrazolone), is a water. Perez-Ruiz et al.[9] employed a glassy carbon electrode as detector in an amperometric flow cell This flow injection procedure presented a linear response in the dipyrone concentration range from 3.0 x 10-6 to 3.0 x 10-5 mol L-1 in an ammonia buffer solution (pH 9.0) at a potential of 0.4 V vs Ag/AgCl. The flow injection amperometric simultaneous determination of dipyrone, ascorbic acid, dopamine and epinephrine using modified microelectrodes, together with multivariate calibration analysis was proposed by Matos et al.[10] It was based on a multi-channel detection system, coupled to a flow cell containing an array of modified microelectrodes. The preparation, properties and application of a carbon paste electrode modified with the N,N-ethylenebis(salicylideneiminato) oxovanadium(IV) complex ([VO(Salen)]) for voltammetric determination of dipyrone in pharmaceutical formulations is reported. Cyclic voltammetric measurements were performed with an Autolab/PGSTAT-30 (Eco Chemie) potentiostat/galvanostat connected to a microcomputer that was controlled by the software GPES2 version 4.8
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