Abstract
Chlorpromazine was used as a homogeneous electrocatalyst in the oxidation of captopril. The anodic peak current of chlorpromazine was increased substantially in the presence of low concentrations of captopril (pH 4). Cyclic voltammetry and chronoamperometry were used to study the kinetics of the catalytic electron transfer reaction. The values of electron transfer coefficient () and catalytic rate constant () were estimated to be 0.34 and , respectively. Linear sweep voltammetry was used for the determination of captopril in the presence of chlorpromazine. A linear calibration curve was obtained in the concentration range of captopril of 10.0–300.0 μM, with a limit of detection of 3.65 μM. The relative standard deviation (RSD%) for 5 replicate measurements of captopril (100 μM) was 1.96%. The method was applied to the determination of captopril in pharmaceutical formulations and blood serum samples with satisfactory results.
Highlights
Captopril (CAP), 1-(3-mercapto-2-D-methyl-1-oxopropyl) proline (Scheme 1(a)), is an oral drug and a member of a class of drugs called angiotensin-converting enzyme (ACE) inhibitors
Cyclic voltammetry (CV) and chronoamperometry were used to characterize the electrochemical properties of CPZ and to investigate its electrocatalytic effect on the CAP oxidation
The electrochemical behavior of CPZ was studied by cyclic voltammetry, and the results obtained were similar to previous reports [31]
Summary
Captopril (CAP), 1-(3-mercapto-2-D-methyl-1-oxopropyl) proline (Scheme 1(a)), is an oral drug and a member of a class of drugs called angiotensin-converting enzyme (ACE) inhibitors. CAP has been widely used as antihypertensive drug and to moderate heart failure [1]. It normally works by lowering blood levels of angiotensin enzyme, to help relax the blood vessels and lower blood pressure. Chlorpromazine (CPZ, Scheme 1(b)), an antipsychotic drug, was used as a suitable homogeneous mediator in the electrooxidation of CAP. Cyclic voltammetry (CV) and chronoamperometry were used to characterize the electrochemical properties of CPZ and to investigate its electrocatalytic effect on the CAP oxidation. Kinetic parameters such as electron transfer coefficient and the rate constant of catalytic reaction were estimated. Scheme 1: Chemical structures of (a) captopril and (b) chlorpromazine
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
