Abstract
A novel electrochemical sensing platform was designed and prepared for the simultaneous detection of sumatriptan and naproxen by exploiting the prowess of the Fe3O4@ZIF-8 nanoparticles (NPs); as-synthesized Fe3O4@ZIF-8 NPs were characterized by energy-dispersive X-ray spectroscopy, fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy (FESEM), transmission electron microscopy and thermal gravimetric analysis. The immobilized Fe3O4@ZIF-8 NPs on a screen printed graphite electrode (SPGE) was evaluated electrochemically via cyclic voltammetry, linear sweep voltammetry, and differential pulse voltammetry as well as chronoamprometery means; Fe3O4@ZIF-8/SPGE exhibited good sensing performance for sumatriptan in a range of 0.035–475.0 µM with detection limit of 0.012 µM. Also, Fe3O4@ZIF-8/SPGE exhibited good sensing performance for naproxen in a range of 0.1–700.0 µM with detection limit of 0.03 µM. The modified electrode showed two separate oxidative peaks at 620 mV for sumatriptan and at 830 mV for naproxen with a peak potential separation of 210 mV which was large enough to detect the two drugs simultaneously besides being stable in the long-run with considerable reproducibility. Real sample analyses were carried out to identify the function of fabricated electrode in sensing applications wherein trace amounts of sumatriptan and naproxen could be identified in these samples.
Highlights
A novel electrochemical sensing platform was designed and prepared for the simultaneous detection of sumatriptan and naproxen by exploiting the prowess of the Fe3O4@Zeolitic imidazolate frameworks (ZIFs)-8 nanoparticles (NPs); as-synthesized Fe3O4@ZIF-8 NPs were characterized by energy-dispersive X-ray spectroscopy, fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy (FESEM), transmission electron microscopy and thermal gravimetric analysis
The results showed a sensitive sensor to analyze sumatriptan and naproxen in actual samples
A Fe3O4@ZIF-8 NPs has been utilized as a novel electrode modifier material for the detection of sumatriptan
Summary
A novel electrochemical sensing platform was designed and prepared for the simultaneous detection of sumatriptan and naproxen by exploiting the prowess of the Fe3O4@ZIF-8 nanoparticles (NPs); as-synthesized Fe3O4@ZIF-8 NPs were characterized by energy-dispersive X-ray spectroscopy, fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy (FESEM), transmission electron microscopy and thermal gravimetric analysis. Despite the increasing application of the triptans, the non-steroidal anti-inflammatory drugs are still distributed at the highest frequency to treat acute migraines such as naproxen as effective nonspecific analgesic and anti-inflammatory medication, prescribed for diverse pains and inflammatory syndromes, namely m igraines[8]. In this impediment, the drug’s analgesic effects relieve the headache on one hand, while the anti-inflammatory effects decrease the neurogenic inflammations in the trigeminal ganglion on the other hand. The simultaneous detection of these medications in biological fluids and pharmaceutical formulations is very important[24]
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