Abstract
Electropolymeric film of pyrrole-alkylammonium (A2) cationic surfactant and multi-wall carbon nanotubes (MWCNTs) composite was firstly used to absorb Fe(CN)63−/4− ions as electrochemical markers to develop amperometric assay for electrochemically inactive heparin. The electrochemical behaviors of the modified platinum electrodes were characterized by cyclic voltammetry and electrochemical impedance spectroscopy. A quite stable and well-defined redox peaks of the confined Fe(CN)63−/4− with negatively shifted potentials compared to the Fe(CN)63−/4\\− in aqueous solution were observed at Fe(CN)63−/4−/polyA2-MWCNTs/Pt. Importantly, the ion exchange of the small anions, Fe(CN)63−/4− by polyanions, heparin at polyA2-MWCNTs films was observed. Thereafter, an amperometric assay for heparin based on anion exchange at Fe(CN)63−/4−/polyA2-MWCNTs/Pt was developed. The linear range to detect heparin with differential pulse voltammetry (DPV) is from 0.1 to 8.0 μM with the limit of detection of 0.1 μM.
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