Abstract

An oversimplified and sensitive sensor based on MoWS2-modified screen-printed electrode (MoWS2/SPE) was designed in this study for detecting gliclazide (GLZ) and glibenclamide (GLB) that are two widespread employed drugs in treating noninsulin-dependent diabetes mellitus. MoWS2 exhibited very good electrocatalytic activities toward oxidation of GLZ and GLB in comparison with bare SPE in 0.1 M PBS, and the isolated capacities of oxidation peak assured concurrent determination of GLZ with widespread linear range between 0.06 and 500.0 μM. Determination limit of GLZ has been 18.0 nM (S/N = 3). MoWS2/SPE has good steadiness, repeatability, and reproducibility. This procedure has had a successful application in detecting GLZ and GLB in their biological and pharmaceutical specimens with acceptable recovery.

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