Abstract
The behavior of fluvoxamine (FVX) was studied by square-wave techniques, leading to two methods for its determination in aqueous samples (pH 2.0 and 4.7) and pharmaceuticals formulations. The application of the square-wave mode shows the determination of FVX between 2×10–8 and 3×10–6 molL–1. FVX gave an adsorptive stripping voltammetric peak at the hanging mercury drop electrode at –0.76 V, using an accumulation potential of –0.50 V. By the stripping technique, FVX proved to be more sensitive, yielding signals five times larger than those obtained by applying a square-wave scan without the previous accumulation. The calibration plot to determine FVX was linear in the range 5×10–9 and 1×10–6 molL–1 by stripping mode. The relative standard deviations obtained for concentration levels of FVX as low as 1.5×10–6 molL–1 with square-wave was 3.54 % (n=10) and for 6.0×10–7 molL–1 with stripping square-wave was 2.39 % (n=10) in the same day. The two proposed methods (SW and SWAdSV) were applied to the determination of fluvoxamine in two Spanish commercial product (Dumirox 50 and Dumirox 100) with very good recoveries respect to the labelled values.
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