Abstract
The electrochemical behavior of ceftazidime (CFZ) at four different kinds of electrodes viz. static mercury drop electrode (SMDE), controlled growth mercury electrode (CGME), glassy carbon electrode (GCE) and carbon paste electrode (CPE) has been presented. Optimal operational parameters have been selected for the drug preconcentration and determination in aqueous medium. Down to 2×10 −10 M CFZ is achieved as detection limit at the CGME. Modification of the CPE with polyvinyl alcohol (PVA) enhances both the sensitivity and selectivity for the drug accumulation and, therefore, its determination at very low levels. Application of the proposed method for CFZ analysis in spiked urine samples or those taken after metabolism has been easily assessed. Down to 1×10 −9 M CFZ (0.695 ng ml −1) could be easily achieved in such samples.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
