Abstract
The electrochemical oxidation of alfuzosin was investigated by cyclic, linear sweep, differential pulse and square-wave voltammetry at glassy carbon disk electrode. Alfuzosin hydrochloride showed a well-defined anodic wave in Britton-Robinson and phosphate buffers over the pH range 2–7.5. For analytical purposes, a very well resolved diffusion controlled voltammetric peak was obtained in phosphate buffer at pH 6.0 for differential pulse and square-wave voltammetric techniques. The linear response was obtained in the ranges of 6×10−7 M – 1×10−4 M for both tecniques. Detection limits were found 1.56×10−7 M for DPV and 6.2×10−8 M for SWV. Based on this study, simple, rapid, selective and sensitive two voltammetric methods were developed for the determination of the alfuzosin in tablet dosage form, human serum and simulated gastric juice.
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