Abstract
Single Ca-activated K channels (C channels) were identified in cell-attached patches in Helix neurons. The respective effects of membrane potential and calcium on the opening probability P o were separated by using Ca-free filled patch electrodes. C channels were found to be highly voltage-dependent, with an e-fold increase in P o per 15 mV increase in potential. The location of the P o(V) curve on the voltage axis was dependent on the intracellular Ca concentration. These data indicate that C channels provide the cell with a powerful repolarizing mechanism.
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