Abstract
Voltage sensor domains comprise four transmembrane segments (S1 to S4) and are responsible for sensing changes in membrane potential and controlling gating of the pore domain (S5 and S6) in voltage-gated ion channels. Sasaki et al. (see the Perspective by Miller) have identified a protein consisting primarily of a voltage-sensor domain (VSD) that appears to mediate voltage-gated proton currents. The proton currents exhibit pH-dependent gating and are sensitive to zinc ion concentrations, features that are characteristic of voltage-gated proton channels. M. Sasaki, M. Takagi, Y. Okamura, A voltage sensor-domain protein is a voltage-gated proton channel. Science 312 , 589-592 (2006). [Abstract] [Full Text] C. Miller, Lonely voltage sensor seeks protons for permeation. Science 312 , 534-535 (2006). [Summary] [Full Text]
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
