Abstract
The effects of Al3+on Na+and K+channel activities in rat and rabbit hippocampal neurons have been examined. Al3+mediated a pronounced voltage-dependent inhibition of single Na+channel activities in inside-out patches excised from neuronal membranes. The reduction in channel activity was more substantial under defined conditions, particularly when changing the holding potential from −120 to −80 mV. This voltage-dependent block indicates that Al3+can mainly inhibit the excitation of neurons with less negative resting potentials. The observed effect may be related to the pathogenetic mechanism of the specific action of Al3+on defined types of neurons affected in neurodegenerative disorders such as Alzheimer's disease.
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