Abstract
We describe a 35-year-old Caucasian woman with a bilateral loss of vision progressed over 10 days, showing optic disk oedema at examination. Serological screening and Cerebrospinal Fluid (CSF) analysis excluded any infective, neoplastic, granulomatous or rheumatologic disorder.
Highlights
Vogt-Koyanagi-Harada (VKH) syndrome is a rare autoimmune disorder related to a T-lymphocyte-mediated response against melanocyte tyrosinase-related proteins
Since we were first suspecting for a neurological disorder, brain Magnetic Resonance (MR) imaging was performed and the axial T2 and T1-sequences showed a bilateral thickening of the choroid, and few small periventricular white matter lesions with no contrast-enhancement (Figure 1)
We asked an ophthalmological review confirming bilateral serous retinal detachments, and the Optical Coherence Tomography (OCT) evidenced areas of subretinal fluid
Summary
Vogt-Koyanagi-Harada syndrome, Bilateral loss of vision, Steroid-responsive autoimmune loss of vision Vogt-Koyanagi-Harada (VKH) syndrome is a rare autoimmune disorder related to a T-lymphocyte-mediated response against melanocyte tyrosinase-related proteins. Diagnostic criteria include: Bilateral choroiditis with bullous serous retinal detachments or focal areas of subretinal fluid, neurological/auditory symptoms (meningismus, tinnitus), and integumentary features (alopecia, poliosis, vitiligo) [2].
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