Abstract
The cause of degeneration of nigrostriatal dopamine (DA)neurons in idiopathic Parkinson disease (PD) is stillunknown. Intraneuronally, DA is largely confined to synapticvesicles by the vesicular monoamine transporter (VMAT2),which protects against DA metabolic degradation and asso-ciated toxicity. Indeed, defects in cytosolic handling of DAincrease levels of DA-generated oxy- radicals, ultimatelyresulting in the degeneration of DAergic neurons.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Movement disorders : official journal of the Movement Disorder Society
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
