Abstract
Vladimir Sertić was a pioneer of bacteriophage research in the period between the two world wars. He was born and educated in Croatia, where he made his initial discoveries, and joined Félix d'Herelle's Laboratoire du Bactériophage in Paris in 1928. Original documents and a box with hundreds of sealed bacteriophages samples were kept in Sertić's Zagreb home for decades. Following Vladimir's death, his sister passed this archival material to Professor Zdravko Lacković in 1989. Some years later, these artefacts were opened and studied. Additionally, we conducted a literature search using the term ‘Vladimir Sertić’ in the databases PubMed and Google Scholar. After a detailed examination of these data, we established a chronology of his work and compiled a list of his scientific publications. A complete bibliography, with the exception of those publications already cited here, is provided as an appendix. Sertić's key contributions included the exploration of the properties of phage lysins, the devising of a uniform bacteriophage classification system and, in collaboration with his protégé, Nikolai Boulgakov, the isolation of numerous bacteriophage strains, including the famous φX174. Finally it was Sertić's pioneering work in Zagreb that offered confirmation that phages are live agents.
Highlights
Vladimir Sertić was a pioneer of bacteriophage research in the period between the two world wars
Because of the growing problem of antibiotic resistance of bacteria, there has been a recent revival of interest in bacteriophage therapy.[1]
Vladimir Sertić was a Croatian microbiologist who in the later phase of his career held the position of scientific director at d’Herelle’s private institute in Paris, the Laboratoire du Bactériophage, and whose scientific contribution to research and application of phage therapy and lysins was only partially described in Croatian-language publications.[5]
Summary
Because of the growing problem of antibiotic resistance of bacteria, there has been a recent revival of interest in bacteriophage therapy.[1]. Vladimir Sertić was a Croatian microbiologist who in the later phase of his career held the position of scientific director at d’Herelle’s private institute in Paris, the Laboratoire du Bactériophage, and whose scientific contribution to research and application of phage therapy and lysins was only partially described in Croatian-language publications.[5] Boulgakov ( spelled as Bulgakov or Buljgakov), the younger brother of the famous writer Mikhail, had left his homeland in Ukraine in 1922 because of the communist revolution, and settled in Zagreb He took Yugoslavian citizenship and continued with his medical studies at the School of Medicine.[6] Upon graduation, Nikolai joined Sertić as an assistant, and eventually followed him to Paris.
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