VKORC1 C1173T and VKORC1 G-1639A Gene Polymorphisms in Turkish Behçet’s Patients with Ocular and Non-ocular Involvement

Abstract

Background: Behçet’s disease (BD) is a multisystemic vasculitis with unknown etiology. Vitamin K epoxide reductase complex subunit 1 (VKORC1) is the key enyzme in the formation of active vitamin K that is a cofactor of various coagulation factors. Polymorphisms of the VKORC1 may affect the levels of active forms of vitamin K-dependent coagulation proteins and the tendency to thrombosis. The current study aimed to evaluate the role of VKORC1 gene polymorphisims in ocular and non-ocular Behçet’s disease.Methods: VKORC1 C1173T (rs 9934438) and G-1639A (rs 9923231) gene polymorphisms were evaluated by real-time polymerase chain reaction-based DNA analysis. The frequency of alleles and distribution of genotypes were assessed by the chi-squared test. Genotype distribution and Hardy–Weinberg equilibrium were tested with the χ2 test for quality of fit.Results: The distribution of GG, GA and AA and CC, CT, TT genotypes and the frequency of G,A and C,T alleles were not found to be different between patients and controls (p = 0.5651; p = 0.335 respectively), as well as patients with or without eye involvement (p = 0.9267; p = 0.384 respectively).Conclusion: VKORC1 polymorphisms seem not to be related with the thrombotic state of systemic and ocular Behçet’s disease.